Research Articles

  1. A.M. Gouw, L.Eberlin, K. Margulis, D.Sullivan, G. Toal, L. Tong, R. Zare, D.W. Felsher. Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. PNAS 2017114 (17):4300-4305.
  2. Shroff EH, Eberlin LS, Dang VM, Gouw AM, Gabay M, Adam SJ, Bellovin DI, Tran PT, Philbrick WM, Garcia-Ocana A, Casey SC, Li Y, Dang CV, Zare RN, Felsher, D. W.  MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6539-44. doi: 10.1073/pnas.1507228112. Epub 2015 May 11. PMCID: PMC4450371
  3. A. Le, A.N. Lane, M. Hamaker, S. Bose, A. Gouw, J. Barbi, T. Tsukamoto, C.J. Rojas, B.S. Slusher, H. Zhang, L.J. Zimmerman, D.C. Liebler, R. J. Slebos, P.K. Lorkiewicz, R. M. Higashi, T.W. Fan, C.V.Dang. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metabolism. 2012 Jan 4;15(1):110-21 PMID 22225880 
  4. A. Le, C.R. Cooper, A.M. Gouw, R. Dinavahi, L.M. Deck, R.E. Royer, D.L.V. Jagt, C.V. Dang. Inhibition of Lactate Dehydrogenase A triggers oxidative stress, cell death and diminishes in vivo tumor xenograft growth. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. Epub 2010 Jan 19. PMID 20133848
  5. Y. Xiang, Z.E. Stine, J. Xia, Y. Lu, B.J. Altman, A.L. Hsieh, A.M. Gouw, A. G. Thomas, P. Gao, L. Sun, L. Song, B. Yan, B.S. Slusher, J. Zhuo, L. L. Ooi, C.G.L. Lee, A. Mancuso, A.S.. McCallion, A. Le, S. Rayport, D.W. Felsher, C.V. Dang. On-target inhibition of glutaminase diminishes cell autonomous tumorigenesis. Journal of Clinical Investigations 2015 125(6):2293-306. PMID 25915584
  6. A. Le, Z.E. Stine, C. Nguyen, J. Afzal, P. Sun, M. Hamaker, N. Siegel, A.M. Gouw, B. Kang, S, Yu, R. Cochran, K.A. Sailor, H.J. Song, C.V. Dang. HypoxCR: a novel fluorescence protein reporter system to envisage differential responses of cells to hypoxia. PNAS 2014 111(34): 12486-91 PMID 2511422
  7.  B. J. Altman, A. L. Hsieh, A. Venkataraman, A. M. Gouw, Z. E. Stine, B. Li, P. Goraksha-Hicks, S. Diskin, D. Bellovin, M. C. Simon, J. C. Rathmell, M. A. Lazar, J. M. Maris, D. W. Felsher, J.B. Hogenesch, C. V. Dang.  MYC disruption of the molecular clock in cancer cells. Cell Metab. 2015 Sep 16. pii: S1550-4131(15)00460-X. doi: 10.1016/j.cmet.2015.09.003 PMID 26387865
  8. E.H. Shroff, V.M. Dang, L. Eberlin, A.M. Gouw, M. Gabay, S.J. Adam, D.I. Bellovin, P. Tran, S.C. Casey, Y. Li, R.V. Nair, S. Plevritis, R. Zare, C.V. Dang, D.W. Felsher. Myc Initiates and Maintains Glutamine-Addicted Renal Cell Adenocarcinoma. PNAS 2015 112 (21): 6539-44. PMID 25964345
  9. L. Eberlin, M. Gabay, A. Fan, A.M. Gouw, R. Tibshirani, D.W. Felsher, R. Zare. Alterations of the Lipid Profile in Lymphomas Induced by MYC Overexpression. PNAS 2014 111(29):10450-5. PMID 24994904
  10. S.C. Casey, L. Tong, Y.Li, R. Do, S. Walz, K. Fitzgerald,  A.M. Gouw, V. Baylot, I. Guetgemann, M. Eilers, D. W. Felsher. MYC regulates the Anti-Tumor Immune Response through CD47 and PD-L1. Science 2016 Apr 8;352(6282):227-31.